The only issues I've encountered were related to nautilus extensions.
Bugs are open for all of them and I submitted a PR for an rpmfusion
package.

However, I think that for people on Workstation who
encrypt/decrypt/sign files through nautilus (and who are not
comfortable with a terminal), the loss of seahorse-nautilus is going
to be a significant problem. Could anyone take a look to see if it can
be patched to work on F37? I was able to get the compilation going up
to a point, but the subsequent errors were beyond my knowledge.