As can be found here: https://mariadb.com/kb/en/library/what-is-the-goal-of-mariadb/
MariaDB is not a drop-in replacement for MySQL anymore. They are "on the user level, broadly compatible".

From devel POV it means, you has to choose, agains which you will compile your software.
From user POV it means, you shouldn't easily cross a functionality which differ, but they are there.
From upstream POV it means, they ususaly has to write their code in such a way, it will compile fine with both. (That mostly meant stop using symbols out of specification and stop using hardcoded paths) 

MariaDB has now both connector C and ODBC in Fedora, which should be used with it, rather than mysql-connector-odbc. On the other hand, mysql-connector-odbc was changed to build back against MySQL (instead of MariaDB)

Nowadays, all of the (applicable) software in F27+ is being compiled against MariaDB.
I still try to support installing client X server packages one from MariaDB and other from MySQL, as well as using connectors vice versa. (That's one thing a Fedora CI will help me greatly in the future)

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