Re: [fedora-medical] Drug interactions

[Eric Maeker]

Hi,

The "question of the day" for the FreeMedForms project is: 
    What is the exact pertinence of the drug drug interaction (DDI) engine/database of FreeMedForms?

I've computed the maximum DDI available. The script evaluates the number of available interactions per level of risk using pairs of international non-proprietary names (INN) extracted from the ATC classification. This script does not use a real drug database, only the INN which are unique. All interactions come with a full description of the risks and sometimes with a possible management of the risk (in french and in english).

Here are the results:

Contre-indication................................. 2985    2%       } Are severe (level 1)
Déconseillée...................................... 5413    5%     }  
Interaction de la glycoprotéine P................. 9963    9%     } Are important (level 2)
Interaction du cytochrome P450.................... 6756    6%     }  
A prendre en compte............................... 64298   61%  }
Précaution d'utilisation.......................... 13934   13%  } Are information (level 3)
Information....................................... 618     0%   }

Total DDI per INN pair............................ 103967  100%

Now think that one drug can contain X interacting molecules...

The question is now:
    What is the exact pertinence of the drug database script when it needs to link drugs component to ATC?

And this question is answered in each database, using a "pertinence index", which represent the percentage of all drug components linked to ATC (we believe that 75% is acceptable, 85% is a near-to-reality, 100% is only-commercial). We may improve this "pertinence index", because users don't want to miss a *severe* DDI. And all of these severe DDI should be tested... by hand. Testers are welcome and can have a full access to the drugs database with DDI. We have to test drugs database from these countries: France, Belgium, USA, Canada, South Africa (and very partially Portugal). Only MD and pharmaceutists can do this job. Please contact us: [e-mail].

Eric, freemedforms.com

Drug interactions

[Eric Maeker]

Hi

I've updated the DDI to the 2012 update of the french ANSM (french gouv drug agency).

ENGLISH: http://www.freemedforms.com/en/news/freemedforms/ddi2012
    FRENCH: http://www.freemedforms.com/fr/news/freemedforms/ddi2012

Eric, freemedforms.com