I use Fedora since its first release to power tens of servers. Today I have servers running KVM infrastructures, Ceph, the core monitoring system of a nuclear power plant (we are migrating from F23 to F25 on July), scientific calculations servers, my own laptop, backup servers, samba servers, web services, and I probably forget a few!
I started with Fedora because it used to have the latest drivers for new hardware. Nowadays high end hardware does not change as fast, so you can probable get away with a CentOS distribution.
Normally I install a reasonably recent version on my laptop (I'm running F25 now), then migrate non-critical servers like Zabbix or proxies, and as gain confidence I move the rest.