If you use balsa, in Fedora 26 you may have trouble sending mail (see Bug 1479177 - since upgrade balsa is no longer able to send emails[1]).
balsa uses libesmtp to send the mail, but libesmtp was accidentally built without SSL support (fixed in my Bug 1483350 - libesmtp built w/o SSL support -- compat-openssl10 required[2]). balsa itself should also be built for compat-openssl10.
In the past (e.g., F20 that I upgraded from) a mail server with a self-signed certificate was accepted, but is now rejected with a useless error message. I think that a self-signed cert is OK for submitting email as it is only used to keep the data (and your password) private (fixed in my Bug 1483649 - balsa no longer accepts mail server self-signed certificate[3]).
When composing a message, the toolbar Queue button sends immediately instead of queuing (fixed in my Bug 1483354 - balsa message window Queue toolbar button sends immediately[4]).
[1]: https://bugzilla.redhat.com/show_bug.cgi?id=1479177 [2]: https://bugzilla.redhat.com/show_bug.cgi?id=1483350 [3]: https://bugzilla.redhat.com/show_bug.cgi?id=1483649 [4]: https://bugzilla.redhat.com/show_bug.cgi?id=1483354
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Tony Nelson