[Bug 716400] New: Review Request: MACS - Model-based Analysis for ChIP-Seq

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Summary: Review Request: MACS - Model-based Analysis for ChIP-Seq

https://bugzilla.redhat.com/show_bug.cgi?id=716400

           Summary: Review Request: MACS - Model-based Analysis for
                    ChIP-Seq
           Product: Fedora
           Version: rawhide
          Platform: All
        OS/Version: Linux
            Status: NEW
          Severity: medium
          Priority: medium
         Component: Package Review
        AssignedTo: nobody at fedoraproject.org
        ReportedBy: bloch at verdurin.com
         QAContact: extras-qa at fedoraproject.org
                CC: notting at redhat.com, fedora-package-review at redhat.com
   Estimated Hours: 0.0
    Classification: Fedora
      Story Points: ---


Spec URL: http://verdurin.fedorapeople.org/reviews/MACS/MACS.spec
SRPM URL:
http://verdurin.fedorapeople.org/reviews/MACS/MACS-1.4.0-1.fc16.src.rpm
Description: 

Next generation parallel sequencing technologies made chromatin
immunoprecipitation followed by sequencing (ChIP-Seq) a popular
strategy to study genome-wide protein-DNA interactions, while creating
challenges for analysis algorithms. We present Model-based Analysis of
ChIP-Seq (MACS) on short reads sequencers such as Genome Analyzer
(Illumina / Solexa). MACS empirically models the length of the
sequenced ChIP fragments, which tends to be shorter than sonication or
library construction size estimates, and uses it to improve the
spatial resolution of predicted binding sites. MACS also uses a
dynamic Poisson distribution to effectively capture local biases in
the genome sequence, allowing for more sensitive and robust
prediction. MACS compares favorably to existing ChIP-Seq peak-finding
algorithms, is publicly available open source, and can be used for
ChIP-Seq with or without control samples.

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