Weird USB interactions?

[Tom Horsley]

When I use my AVRISPmkII programmer to fool with the
microcode on my 3D printer motherboard, my mouse and
keyboard apparently get reset. All the settings I made
with xinput disappear and I have to re-apply them.

The ISP is running through the same powered hub as the
keyboard and mouse, maybe something is resetting more
of the USB tree than it should?

Should I report this as a kernel bug? Should I try to
find more information to gather? What is going on here?