Spoke too soon. If I try to get a new certificate on an enrolled host I get this
status: CA_UNREACHABLE ca-error: Server at https://ipa1-sea2.ipa.****.net/ipa/xml failed request, will retry: 907 (RPC failed at server. cannot connect to 'https://ipa1-sea2.ipa.****.net:443/ca/rest/account/login': [SSL: SSL_HANDSHAKE_FAILURE] ssl handshake failure (_ssl.c:1822)).
This reflected in the UI if I go to Authentication > Certificates > Certificate Authorities where I see the same error.
The IPA server listed there is the one where all services started via ipactl start in my previous update.