Compile issues after F27 -> F28 upgrade

I did an upgrade from Fedora 27 to the Fedora 28 beta a while back. (About
a week before final release.) After the update I tried to recompile a
program I use often. The program would compile after a bit of patching,
but it would not start.

Using ldd I was able to determine that the ldconfig database still had old
entries from the Fedora 27 install that had been upgraded/erased.

Is this a known issue or am I just going mad?

perl -pe 's/^\s+//g' *.py